The ESPN broadcast is scheduled to begin at 10 p.m. ET — after Inoue's Japanese countryman and baseball star Shohei Ohtani and the Los Angeles Dodgers take on the Atlanta Braves.

For his Cinco De Mayo Weekend showdown against Vazquez (17-2, 4 KOs), Espinoza will be the warm-up act on the ESPN card headlined by Naoya Inoue’s undisputed junior featherweight title defense against Ramon Cardenas at the T-Mobile Arena.

On Sunday, Vazquez (17-2, 4 KOs) will get another crack to evolve from snakebitten contender to crown holder when he clashes against WBO featherweight champion Rafael Espinoza (26-0, 22 KOs) at the T-Mobile Arena in an ESPN co-main event fight on the Naoya Inoue-Ramon Cardenas undercard.

Mexico's Rafael Espinoza plans to steal the spotlight on Cinco de Mayo Weekend. The 31-year-old Espinoza defends his WBO crown against Edward Vazquez on Sunday, May 4, at T-Mobile Arena in Las Vegas.

Featherweight boxing has long been central to Mexico’s pugilistic tradition, and Rafael “El Divino” Espinoza is ready to honor that legacy on Cinco de Mayo Weekend.